Article

A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

2020-08-12

Abstract excerpt

<h4> Abstract </h4> Cytokine-mediated activation of host immunity is central to the control of pathogens. A key cytokine in protective immunity is interferon-gamma (IFNγ), which is a potent activator of antimicrobial and immunomodulatory effectors within the host. A major role of IFNγ is to induce major histocompatibility complex class II molecules (MHCII) on the surface of cells, which is required for CD4 + T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 832490da-5f58-5a6b-ba4b-457a247d80d2
DOI: 10.1101/2020.08.12.248252

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activationDOI 10.1101/2020.08.12.248252Read

Epigenetic Regulation of Inflammatory NF-κB Target Genes by IFN-γ via IRF1Semantic proximity Read

Beyond Good and Evil: Molecular Mechanisms of Type I and III IFN FunctionsSemantic proximity Read

IL-32 drives inflammatory responses in IFN-γ primed human macrophages via a Myddosome-dependent pathway and is elevated in COVID-19Semantic proximity Read

Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsivenessSemantic proximity Read

Regulation of Macrophage IFNγ-Stimulated Gene Expression by the Transcriptional Coregulator CITED1Semantic proximity Read

Distinct molecular phenotypes involving several human diseases are induced by IFN-λ3 and IFN-λ4 in monocyte-derived macrophages.Semantic proximity Read

UFMylation suppresses Type IFN signaling during <i>Mycobacterium tuberculosis</i> infection of human macrophagesSemantic proximity Read

Interferon Lambda Genetics and Biology in Regulation of Viral ControlSemantic proximity Read

IFNγ initiates TLR9-dependent autoimmune hepatitis in DNase II deficient miceSemantic proximity Read

Regulators of Interferon-Responsive Microglia Uncovered by Genome-wide CRISPRi ScreeningSemantic proximity Read

Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlasSemantic proximity Read

Type I Interferon-Driven Monocyte Dysregulation and MAS-associated CD8 <sup>+</sup> T cells During Macrophage Activation SyndromeSemantic proximity Read