Article

Type I Interferon-Driven Monocyte Dysregulation and MAS-associated CD8 <sup>+</sup> T cells During Macrophage Activation Syndrome

2026-05-26

Abstract excerpt

Macrophage activation syndrome (MAS) is driven by a hyperinflammatory response characterized by aberrant activation of lymphocytes and phagocytes. While monocytes and macrophages are thought to be important in MAS pathogenesis, their role remains poorly understood. We used bulk and single-cell RNA sequencing (RNA-Seq) on sorted monocytes from children with MAS and healthy controls to identify transcriptional chang...

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Literature Corpus work: feec8a0f-d500-51a6-8da3-72e638a93e2e
DOI: 10.64898/2026.05.23.727321

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