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Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlas

2025-12-23

Abstract excerpt

<title>Abstract</title> <p>Interferons (IFNs) orchestrate diverse immune responses, but distinguishing individual IFN contributions in human transcriptomic data is challenging due to overlapping interferon-stimulated gene (ISG) signatures and limited cell-type-specific datasets. To address this, we generated a single-cell transcriptomic atlas of IFN responses by stimulating primary human T, B, NK, and CD14 monocy...

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Literature Corpus work
48a5ed49-73b5-574e-bd89-75c7fcc61550
DOI
10.21203/rs.3.rs-8197575/v1
Open publication

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Dissecting type I and II interferon impacts on human immune cells in disease by a cell type-specific interferon response atlasDOI 10.21203/rs.3.rs-8197575/v1
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