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Article

Distinct molecular phenotypes involving several human diseases are induced by IFN-λ3 and IFN-λ4 in monocyte-derived macrophages.

Genes and immunity - 1 Apr 2022

De Manjarika, Bhushan Anand, Grubbe William S, Roy Subhajit, Mendoza Juan L, Chinnaswamy Sreedhar

Abstract excerpt

Human Interferon (IFN) lambda 3 (IFN-λ3) and IFN-λ4 are closely linked at the IFNL locus and show association with several diseases in genetic studies. Since they are only ~30% identical to each other, to better understand their roles in disease phenotypes, comparative studies are needed. Monocytes are precursors to macrophages (monocyte-derived macrophages; MDMs) that get differentiated under the influence of...

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Identifiers

PMID: 35115664
DOI: 10.1038/s41435-022-00164-w
PMCID: PMC9042695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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