Article

UFMylation suppresses Type IFN signaling during <i>Mycobacterium tuberculosis</i> infection of human macrophages

2024-08-07

Abstract excerpt

<h4>ABSTRACT</h4> Type I Interferons (IFN-I) promote host defense against a wide range of viral infections, but inhibit control of several bacterial pathogens, including Mycobacterium tuberculosis (Mtb). Given the significance of IFN-I signaling in determining Mtb infection outcomes, we sought to uncover new molecular mechanisms that regulate IFN-I during mycobacterial infection, specifically focusing on how IFN...

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Literature Corpus work: 148dac58-64c4-59fa-8b8b-80f46215d40a
DOI: 10.1101/2024.08.07.607094

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