Article

Regulators of Interferon-Responsive Microglia Uncovered by Genome-wide CRISPRi Screening

2025-06-06

Abstract excerpt

Microglia dynamically support brain homeostasis through the induction of specialized activation programs or states. One such program is the Interferon-Responsive Microglia state (IRM), which has been identified in developmental windows, aging, and disease. While the functional importance of this state is becoming increasingly clear, our understanding of the regulatory networks that govern IRM induction remain inco...

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Literature Corpus work: 330b11b3-5647-54f5-aa98-025ed8f360ca
DOI: 10.1101/2025.06.05.658176

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