Article

IL-32 drives inflammatory responses in IFN-γ primed human macrophages via a Myddosome-dependent pathway and is elevated in COVID-19

2025-05-30

Abstract excerpt

<h4>SUMMARY</h4> IFN-γ is secreted by multiple lymphoid subsets in response to antigen stimulation and can reprogram and prime macrophages epigenetically and transcriptionally to increase responses to inflammatory stimuli such as LPS, IL-1β or TNF-α. IFN-γ-driven M1-like inflammatory macrophage states are shared across human immune-mediated inflammatory diseases (IMIDs) and while IFN-γ is nonredundant for defense...

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Literature Corpus work: 010e6d4a-9288-5531-937c-40b2f0b29192
DOI: 10.1101/2025.05.29.656795

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