Article

IFNγ initiates TLR9-dependent autoimmune hepatitis in DNase II deficient mice

2024-07-16

Abstract excerpt

<h4>ABSTRACT</h4> Patients with biallelic hypomorphic mutation in DNASE2 develop systemic autoinflammation and early-onset liver fibrosis. Prior studies showed that Dnase2 -/- Ifnar -/- double knockout (DKO) mice develop Type I IFN-independent liver inflammation, but immune mechanisms were unclear. We now show that DKO mice recapitulate many features of human autoimmune hepatitis (AIH), including periportal an...

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Literature Corpus work: d3ad64cd-88cb-57d7-9909-f3e76fc76b95
DOI: 10.1101/2024.07.10.602775

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