Back to search

Article

Epigenetic Regulation of Inflammatory NF-κB Target Genes by IFN-γ via IRF1

2024-12-02

Abstract excerpt

The regulation of inflammatory gene expression involves complex interactions between transcription factors (TFs), signaling pathways and epigenetic chromatin-mediated mechanisms. This study investigated mechanisms by which by IFN-γ-mediated priming augments TLR-induced expression of NF-κB target genes in primary human monocytes. IFN-γ priming enhanced the expression of signature inflammatory genes such as IL6 ,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f5350ef1-c1ae-50ee-b629-cea9afb3c4d8
DOI
10.1101/2024.11.26.625557
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Epigenetic Regulation of Inflammatory NF-κB Target Genes by IFN-γ via IRF1DOI 10.1101/2024.11.26.625557
IL-10 Targets IRFs to Suppress IFN and Inflammatory Response Genes by Epigenetic MechanismsSemantic proximity
Selective epigenetic regulation of IFN-γ signature genes by JAK inhibitor in inflammatory diseasesSemantic proximity
The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.Semantic proximity
A genome-wide screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activationSemantic proximity
Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases.Semantic proximity
Early transcriptional effects of inflammatory cytokines reveal highly redundant cytokine networksSemantic proximity
Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsivenessSemantic proximity
Regulating IRFs in IFN Driven DiseaseSemantic proximity
Stimulator of interferon genes is required for Toll-Like Receptor-8 induced interferon responseSemantic proximity
Opposing Regulation of TNF Responses by IFN-γ and a PGE2-cAMP Axis that is Apparent in Rheumatoid and Immune Checkpoint Inhibitor-induced Arthritis IL-1β+ MacrophagesSemantic proximity
Distinct molecular phenotypes involving several human diseases are induced by IFN-λ3 and IFN-λ4 in monocyte-derived macrophages.Semantic proximity
Single-cell analysis of signalling and transcriptional responses to type I interferonsSemantic proximity
Select a neighboring publication to make it the new centre.