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Article

Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsiveness

1 Oct 2019

Abstract excerpt

The type II IFN (IFNγ) enhances antimicrobial activity yet also drives expression of genes that amplify inflammatory responses. Hence, excessive IFNγ stimulation can be pathogenic. Here, we describe a previously unappreciated mechanism whereby IFNγ itself dampens myeloid cell activation. Staining of monocytes fromListeria monocytogenes–infected mice provided evidence of type I IFN–independent reductions in...

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PMID: 31585982
DOI: 10.26508/lsa.201900447

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