Article

A conserved homo-dimerization interface in human IFIT1 provides insights into IFIT interactome assembly

2017-06-21

Abstract excerpt

The Interferon-Induced Proteins with Tetratricopeptide Repeats (IFITs) are a group of potently expressed Interferon Stimulated Genes that mediate antiviral innate immunity. Previous studies have revealed that most IFITs partake in higher order structures, potentially as part of an ‘IFIT interactome’ that results in viral inhibition. Recent crystal structures of a mutated, monomeric form of IFIT1 revealed the molec...

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Literature Corpus work: 5bd2b725-336c-59ba-ab32-7e6080e95d06
DOI: 10.1101/152850

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