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Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis

27 Nov 2014

Abstract excerpt

A major component of the protective antiviral host defense is contributed by the intracellular actions of the proteins encoded by interferon-stimulated genes (ISGs); among these are the interferon-induced proteins with tetratricopeptide repeats (IFITs), consisting of four members in human and three in mouse. IFIT proteins do not have any known enzyme activity. Instead, they inhibit virus replication by binding...

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PMID: 25428874
DOI: 10.1128/jvi.02744-14

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