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IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunity

23 Nov 2022

Abstract excerpt

Interferon-induced transmembrane proteins (IFITMs) are broad spectrum antiviral factors that inhibit the entry of a wide range of clinically important pathogens including influenza A virus, HIV-1, and Dengue virus. IFITMs are thought to act primarily by antagonizing virus-cell membrane fusion in this regard. However, recent work on these proteins has uncovered novel post-entry viral restriction mechanisms. IFITMs...

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PMID: 36435199
DOI: 10.1016/j.jbc.2022.102741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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