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IFIT3 RNA-binding activity promotes influenza A virus infection and translation efficiency

11 Jun 2025

Abstract excerpt

Host cells produce a vast network of antiviral factors in response to viral infection. The interferon-induced proteins with tetratricopeptide repeats (IFITs) are important effectors of a broad-spectrum antiviral response. In contrast to their canonical roles, we previously identified IFIT2 and IFIT3 as pro-viral host factors during influenza A virus (IAV) infection. During IAV infection, IFIT2 binds and enhances...

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PMID: 40497724
DOI: 10.1128/jvi.00286-25

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