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Article

Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity.

EMBO reports - 1 Nov 2016

Compton Alex A, Roy Nicolas, Porrot Françoise, Billet Anne, Casartelli Nicoletta, Yount Jacob S, Liang Chen, Schwartz Olivier

Abstract excerpt

The interferon-induced transmembrane (IFITM) proteins protect host cells from diverse virus infections. IFITM proteins also incorporate into HIV-1 virions and inhibit virus fusion and cell-to-cell spread, with IFITM3 showing the greatest potency. Here, we report that amino-terminal mutants of IFITM3 preventing ubiquitination and endocytosis are more abundantly incorporated into virions and exhibit enhanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27601221
DOI: 10.15252/embr.201642771
PMCID: PMC5090704

Genes

IFITM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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