Article

IFIT1 is rapidly evolving and exhibits disparate antiviral activities across 11 mammalian orders

2024-05-13

Abstract excerpt

Mammalian mRNAs possess an N7-methylguanosine (m7G) cap and 2'O methylation of the initiating nucleotide at their 5' end, whereas certain viral RNAs lack these characteristic features. The human antiviral restriction factor IFIT1 recognizes and binds to specific viral RNAs that lack the 5' features of host mRNAs, resulting in targeted suppression of viral RNA translation. This interaction imposes significant host-...

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Literature Corpus work: aa8cb5ea-6b8f-5531-8d41-baba23d42231
DOI: 10.1101/2024.05.13.593954

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