Article

IFIT3 RNA-binding activity promotes influenza A virus infection and translation efficiency

2025-02-19

Abstract excerpt

Host cells produce a vast network of antiviral factors in response to viral infection. The interferon-induced proteins with tetratricopeptide repeats (IFITs) are important effectors of a broad-spectrum antiviral response. In contrast to their canonical roles, we previously identified IFIT2 and IFIT3 as pro-viral host factors during influenza A virus (IAV) infection. During IAV infection, IFIT2 binds and enhances t...

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Literature Corpus work: a4e512e2-f9f9-5e59-90e5-855169d1b7ba
DOI: 10.1101/2025.02.17.638785

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