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IFITM protein regulation and functions: Far beyond the fight against viruses

18 Nov 2022

Abstract excerpt

Interferons (IFNs) are important cytokines that regulate immune responses through the activation of hundreds of genes, including interferon-induced transmembrane proteins (IFITMs). This evolutionarily conserved protein family includes five functionally active homologs in humans. Despite the high sequence homology, IFITMs vary in expression, subcellular localization and function. The initially described adhesive...

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PMID: 36466909
DOI: 10.3389/fimmu.2022.1042368

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