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Article

Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals

30 May 2016

Abstract excerpt

IFIT (interferon-induced with tetratricopeptide repeats) proteins are critical mediators of mammalian innate antiviral immunity. Mouse IFIT1 selectively inhibits viruses that lack 2'O-methylation of their mRNA 5' caps. Surprisingly, human IFIT1 does not share this antiviral specificity. Here, we resolve this discrepancy by demonstrating that human and mouse IFIT1 have evolved distinct functions using a...

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PMID: 27240734
DOI: 10.7554/elife.14228

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