Article

Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells

2005-01-01

Abstract excerpt

Abstract We reported recently that roscovitine arrested human MCF-7 cancer cells at G2-M phase of the cell cycle and concomitantly induced apoptosis. After roscovitine treatment, the level of wild-type p53 protein strongly increased and p53 was accumulated in the nucleus. Here, we raised the question of which pathway would be involved in roscovitine-induced apoptosis in MCF-7 cells, which are known to be caspase-3...

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Literature Corpus work: 2d3fab7d-a8d7-5151-9704-7638c70e10e8
DOI: 10.1158/1535-7163.113.4.1

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