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Article

Persistent p21Cip1 induction mediates G(1) cell cycle arrest by methylseleninic acid in DU145 prostate cancer cells.

Current cancer drug targets - 1 May 2010

Wang Zhe, Lee Hyo-Jeong, Chai Yubo, Hu Hongbo, Wang Lei, Zhang Yong, Jiang Cheng, Lü Junxuan

Abstract excerpt

The induction of G(1) cell cycle arrest and apoptosis by second-generation selenium compounds (e.g., methylselenol precursors such as methylseleninic acid, MSeA) may contribute to their anti-cancer activities. We have documented previously induction of G(1) arrest and apoptosis by MSeA in association with upregulation of cyclin-dependent kinase inhibitor (CDKI) proteins p21Cip1 and/or p27Kip1 in DU145 prostate...

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Identifiers

PMID: 20370687
DOI: 10.2174/156800910791190238

Genes

CDK2
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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