Article
Activation of p53 by roscovitine-mediated suppression of MDM2 expression.
Oncogene - 31 May 2001
Lu W, Chen L, Peng Y, Chen J
Abstract excerpt
The p53 tumor suppressor is regulated by the MDM2 oncoprotein. Overexpression of MDM2 maintains p53 at low levels and contributes to the functional inactivation of p53 in a subset of tumors. We found that treatment with roscovitine and olomoucin, which were originally developed as cyclin-dependent kinase (CDK) inhibitors, can efficiently stabilize and activate nuclear p53 in tumor cells with MDM2 amplification or...
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