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Article

Stat1-Dependent, p53-Independent Expression of p21 waf1 Modulates Oxysterol-Induced Apoptosis

1 Apr 2002

Abstract excerpt

7-Ketocholesterol (7kchol) is prominent in atherosclerotic lesions where apoptosis occurs. Using mouse fibroblasts lacking p53, p21(waf1), or Stat1, we found that optimal 7kchol-induced apoptosis requires p21(waf1) and Stat1 but not p53. Findings were analogous in a human cell system. Apoptosis was restored in Stat1-null human cells when wild-type Stat1 was restored. Phosphorylation of Stat1 on Ser(727) but not...

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PMID: 11884587
DOI: 10.1128/mcb.22.7.1981-1992.2002

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