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Article

A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug.

Investigational new drugs - 1 Jun 2005

Fimognari Carmela, Sangiorgi Luca, Capponcelli Silvia, Nüsse Michael, Fontanesi Silvia, Berti Fausto, Soddu Silvia, Cantelli-Forti Giorgio, Hrelia Patrizia

Abstract excerpt

We investigated apoptosis induction by sulforaphane on three cell lines characterized by a different p53 status. In particular, we used p53-knock-out fibroblasts from newborn mice transfected with the p53-Ser220 mutation, observed in Li-Fraumeni Syndrome patients, as a model of mutated p53 status. Moreover, immortalized fibroblasts from newborn mice expressing or lacking p53 (p53 +/+ and p53-/-, respectively)...

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Identifiers

PMID: 15868375
DOI: 10.1007/s10637-005-6727-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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