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Article

Rapid onset of nucleolar disintegration preceding cell cycle arrest in roscovitine‐induced apoptosis of human MCF‐7 breast cancer cells

9 Jun 2003

Abstract excerpt

The aim of our study was to explore the antiproliferative and pro-apoptotic action of roscovitine (ROSC) on human breast cancer MCF-7 cells. We examined the effect of ROSC on cell proliferation, cell cycle progression, nucleolar morphology, posttranslational modifications of histones as well as on induction of apoptosis. The effects of ROSC on the argyrophilic nucleolar organizer regions (AgNORs) and nucleolar...

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PMID: 12845642
DOI: 10.1002/ijc.11290

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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