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Article

Etoposide induces cell death via mitochondrial-dependent actions of p53

5 Aug 2015

Abstract excerpt

BACKGROUND: Etoposide has been used clinically in cancer treatment, as well as in numerous research studies, for many years. However, there is incomplete information about its exact mechanism of action in induction of cell death. METHODS: Etoposide was compared at various concentrations to characterize the mechanisms by which it induces cell death. We investigated its effects on mouse embryonic fibroblasts (MEFs)...

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PMID: 26251638
DOI: 10.1186/s12935-015-0231-z

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