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Article

Identification of the region required for the antiapoptotic function of the cyclin kinase inhibitor, p21.

Archives of biochemistry and biophysics - 1 Nov 2004

Nakamura Kentarou, Arai Daisuke, Fukuchi Kunihiko

Abstract excerpt

The CDK inhibitor, p21, exhibits an antiapoptotic or proapoptotic effect, in addition to its anti-proliferative effect, depending on the conditions. To define the apoptosis-regulatory function of p21, we constructed cells that stably express C-terminal deletion mutants of p21 (full length 164aa), 1-157, 1-147 or 1-128, and evaluated the apoptotic response of these cells. The AnnexinV positive cell fraction after...

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Identifiers

PMID: 15464725
DOI: 10.1016/j.abb.2004.07.032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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