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Article

Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis.

Journal of the National Cancer Institute - 16 Jul 1997

Gomez-Manzano C, Fueyo J, Kyritsis A P, McDonnell T J, Steck P A, Levin V A, Yung W K

Abstract excerpt

BACKGROUND: Alterations of the p53 (also called TP53) gene are one of the most common abnormalities in gliomas. We have previously reported that restoration of wild-type p53 protein function in glioma cells results in programmed cell death (apoptosis). Since p53 functions are mediated by genes th...

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Source

Identifiers

PMID: 9230885
DOI: 10.1093/jnci/89.14.1036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9230885-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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