Article
Mechanisms of proteasome inhibitor PS-341-induced G(2)-M-phase arrest and apoptosis in human non-small cell lung cancer cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2003
Ling Yi-He, Liebes Leonard, Jiang Jian-Dong, Holland James F, Elliott Peter J, Adams Julian, Muggia Franco M, Perez-Soler Roman
Abstract excerpt
PURPOSE: PS-341 is a novel dipeptide boronic acid proteasome inhibitor with in vitro and in vivo antitumor activity that induces mechanisms of apoptosis by unknown mechanisms. EXPERIMENTAL DESIGN: Human non-small cell lung cancer cell lines were used to investigate effects PS-341 on cell proliferation, cell cycle progression, and the induction of apoptosis. RESULTS: PS-341 was 38-360-fold more cytotoxic against...
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