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Article

Roscovitine Modulates DNA Repair and Senescence: Implications for Combination Chemotherapy

15 Nov 2005

Abstract excerpt

PURPOSE: Treatment of tumor cells by chemotherapy activates a series of responses ranging from apoptosis to premature senescence and repair. Survival responses are characterized by inhibition of cyclin-dependent kinases. Because inhibition of cyclin-dependent kinases represents a distinctive feature of DNA damage-induced prosurvival responses, we investigated the possibility that the cyclin-dependent kinase...

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PMID: 16299248
DOI: 10.1158/1078-0432.ccr-05-1042

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