Article

Interrogation of cancer gene dependencies reveals novel paralog interactions of autosome and sex chromosome encoded genes

2021-05-23

Abstract excerpt

Genetic networks are characterized by extensive buffering. During tumour evolution, disruption of these functional redundancies can create de novo vulnerabilities that are specific to cancer cells. In this regard, paralog genes are of particular interest, as the loss of one paralog gene can render tumour cells dependent on a remaining paralog. To systematically identify cancer-relevant paralog dependencies, we se...

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Literature Corpus work: 0c4bc1ec-b82d-5ae1-b6ca-254ab1405b1b
DOI: 10.1101/2021.05.21.445116

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