Discovery of synthetic lethal and tumor suppressive paralog pairs in the human genome

Abstract excerpt

CRISPR knockout screens have accelerated the discovery of important cancer genetic dependencies. However, traditional CRISPR-Cas9 screens are limited in their ability to assay the function of redundant or duplicated genes. Paralogs in multi-gene families constitute two-thirds of the protein-coding genome, so this blind spot is the rule, not the exception. To overcome the limitations of single gene CRISPR knockout...

Topics

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• Computational Biology
• Epistasis, Genetic
• Gene Expression Regulation, Neoplastic
• Gene Regulatory Networks
• Genes, Neoplasm
• Loss of Function Mutation
• Mutation
• Neoplasms

Identifiers and source

Literature Corpus work

09ec976c-cb78-578d-9d19-82cd36add537

DOI

10.1101/2020.12.20.423710