Article
Convergent mutations in tissue-specific regulatory regions reveal novel cancer drivers
2020-08-22
Abstract excerpt
Although much effort has been devoted to identifying coding mutations across cancer types, regulatory mutations remain poorly characterized. Here, we describe a framework to identify non-coding drivers by aggregating mutations in cell-type specific regulatory regions for each gene. Application of this approach to 2,634 patients across 11 human cancer types identified 60 pan-cancer, 22 pan-breast and 192 cancer spe...
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Identifiers and source
- Literature Corpus work
- 18d6721e-96ae-5475-872f-66ec419381fc
- DOI
- 10.1101/2020.08.21.239954