Article

Systematic lncRNA mapping to genome-wide co-essential pathways uncovers cancer dependency on uncharacterized lncRNAs

2022-02-04

Abstract excerpt

<h4>ABSTRACT</h4> Quantification of gene dependency across hundreds of cell lines using genome-scale CRISPR screens have revealed co-essential pathways/modules and critical functions of uncharacterized genes. In contrast to protein-coding genes, robust CRISPR-based loss-of-function screens are lacking for long non-coding RNAs (lncRNAs), which are key regulators of many cellular process, leaving many essential lnc...

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Literature Corpus work: fb5d9d6e-e92c-5293-ab47-d10c43283d13
DOI: 10.1101/2022.02.03.478941

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