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Article

Mapping the landscape of genetic dependencies in chordoma

6 Apr 2023

Abstract excerpt

Identifying the spectrum of genes required for cancer cell survival can reveal essential cancer circuitry and therapeutic targets, but such a map remains incomplete for many cancer types. We apply genome-scale CRISPR-Cas9 loss-of-function screens to map the landscape of selectively essential genes in chordoma, a bone cancer with few validated targets. This approach confirms a known chordoma dependency, TBXT (T;...

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PMID: 37024492
DOI: 10.1038/s41467-023-37593-8

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