Article
Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer
2018-08-09
Abstract excerpt
Extensive transcriptional alterations are observed in cancer, many of which activate core biological processes established in unicellular organisms or suppress differentiation pathways formed in metazoans. Through rigorous, integrative analysis of genomics data from a range of solid tumours, we show many transcriptional changes in tumours are tied to mutations disrupting regulatory interactions between unicellular...
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Identifiers and source
- Literature Corpus work
- 5035802c-b91b-5313-b3af-5b830f7e5a22
- DOI
- 10.1101/388363