Article

Using Cancer Profiles to Identify Synthetic Lethal Therapeutic Targets and Predictive Biomarkers in Cancer Gene Dependency Data

2025-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Large scale loss-of-function screens utilising CRISPR or siRNA can provide profound insights into the importance of individual genes for the survival of a cancer cell and can drive the identification of therapeutic targets and biomarkers, and the development of targeted drugs. However, the analysis of these data and the substantial bodies of metadata that relate to them, is technically challengi...

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Literature Corpus work: 6752c336-aaba-5feb-920b-89a334618c3f
DOI: 10.1101/2025.04.07.647559

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