Article

Gene essentiality in cancer cell lines is modified by the sex chromosomes

2021-11-04

Abstract excerpt

Human sex differences are thought to arise from gonadal hormones and genes on the sex chromosomes. Here we studied how sex and the sex chromosomes can modulate the outcome of mutations across the genome. We used the results of genome-wide CRISPR-based screens on 306 female and 396 male cancer cell lines to detect differences in gene essentiality between the sexes. By exploiting the tendency of cancer cells to lose...

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Literature Corpus work: de001152-a1c3-54c8-b20f-0d27260b1665
DOI: 10.1101/2021.11.04.467330

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