Article

Systematic multivariate analysis of chromatin complex dependencies reveals Set1C/COMPASS as a melanoma-enriched epigenetic vulnerability

2026-02-14

Abstract excerpt

Epigenetic dysregulation is a common feature of cancer. It creates vulnerabilities arising from an increased reliance on chromatin-based mechanisms that sustain malignant transcriptional states. While many chromatin regulators are broadly required for cellular viability, others function in a context-dependent manner across distinct oncogenic settings, tissue lineages, and differentiation states. Moreover, chromati...

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Literature Corpus work: 369c1881-3b3c-5d79-bd25-d15723402c91
DOI: 10.64898/2026.02.13.705694

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