Comprehensive Interrogation of Synthetic Relationships in the Human DNA Damage Response

Abstract excerpt

The DNA damage response (DDR) is a multi-faceted network of pathways that preserves genome stability. Unraveling the complementary interplay between these pathways remains a challenge. Here, we comprehensively mapped genetic interactions for all core DDR genes using combinatorial CRISPRi screening. We discovered myriad new connections, including interactions between cancer genes and small molecule targets. We focu...

Topics

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• CRISPR-Cas Systems
• DNA Breaks, Double-Stranded
• DNA End-Joining Repair
• DNA Repair
• Gene Knockout Techniques
• Mutation
• Tumor Suppressor p53-Binding Protein 1
• Werner Syndrome Helicase

Identifiers and source

Literature Corpus work

9e610970-c62e-5a55-b645-324511dcda74

DOI

10.1101/2023.08.18.553865