Article

CRISPR-enabled genetic screens identify synthetic lethal targets across frequently altered cancer drivers

2026-01-25

Abstract excerpt

<h4>Summary</h4> Synthetic lethality (SL) provides a treatment paradigm for targeting cancer with alterations in driver genes that are not conventionally druggable, including loss-of-function (LoF) mutations in tumor suppressor genes and gain-of-function (GoF) alterations in oncogenes. We undertook a series of genome-wide CRISPR screens using functionally validated isogenic cell lines and also conducted a large-s...

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Literature Corpus work: 3432f3bd-39fd-5a8c-88ff-e15e053a9f69
DOI: 10.64898/2026.01.25.701589

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