Article

Reproducible autosomal gene expression changes with loss of typical X and Y complement across tumor types

2025-09-25

Abstract excerpt

Although there are known sex differences in cancer incidence, severity, and treatment, the sex chromosomes are typically excluded from genomic analyses because of the unique technical challenges associated with assessing their copy number, sequence variation, and expression. Here we assess sex chromosome complement in three widely-used human genomics datasets from normal (non-cancerous) tissues, primary tumors, an...

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Literature Corpus work: ce97cea8-1c5f-586a-aa63-fdc1a0e4132b
DOI: 10.1101/2025.09.24.678401

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