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A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases

2024-11-25

Abstract excerpt

<h4>Background</h4> Recent studies highlight the critical role of microglia in neurodegenerative disorders, and emphasize the need for humanized models to accurately study microglial responses. Human-mouse microglia xenotransplantation models are a valuable platform for functional studies and for testing therapeutic approaches, yet currently those models are only available for academic research. This hampers thei...

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Literature Corpus work
fd9a09fc-7d6f-5ac5-9de2-ab1e50fdd32d
DOI
10.1101/2024.11.25.624854
Open publication

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A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseasesDOI 10.1101/2024.11.25.624854
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