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An integrated human forebrain organoid reveals microglia-mediated CD8⁺ T cell recruitment and neuroimmune dysfunction in Alzheimer’s disease pathology

2026-05-28

Abstract excerpt

Genetic evidence implicates immune dysfunction in Alzheimer’s disease (AD), yet the neuroimmune mechanisms operating in human tissue remain poorly defined. Here, we establish a modular human forebrain organoid platform that systematically integrates iPSC-derived microglia and CD8 + T cells to reconstitute multicellular Alzheimer’s disease pathology. This system enables functional interrogation of both innate and...

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Literature Corpus work
38420496-e4d0-5015-835f-89a0aae2a0e8
DOI
10.64898/2026.05.25.727443
Open publication

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An integrated human forebrain organoid reveals microglia-mediated CD8⁺ T cell recruitment and neuroimmune dysfunction in Alzheimer’s disease pathologyDOI 10.64898/2026.05.25.727443
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