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Humanized tauopathy chimeras uncover microglial and lncRNA strategies for neuroprotection

2026-07-03

Abstract excerpt

Human genetics implicates innate immunity as a key modifier of tau toxicity, yet human-specific neuroimmune mechanisms remain difficult to test in vivo. Here, we developed HuMiNAX, the first humanized iPSC-based neuroimmune xenograft model of tau-associated neurodegeneration, enabling human microglia to interact with human neurons and astrocytes in the adult mouse brain. In HuMiNAX, tau seeding induced aggregation...

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Literature Corpus work
70c28a6a-3b17-5820-8b36-ce78574b0e72
DOI
10.64898/2026.07.02.736124
Open publication

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Humanized tauopathy chimeras uncover microglial and lncRNA strategies for neuroprotectionDOI 10.64898/2026.07.02.736124
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