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Article

HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model

30 Nov 2023

Abstract excerpt

ABSTRACT The central nervous system (CNS) is a major human immunodeficiency virus type-1 (HIV-1) reservoir. Microglia are the primary target cell of HIV-1 infection in the CNS. Current models have not allowed the precise molecular pathways of acute and chronic CNS microglial infection to be tested with in vivo genetic methods. Here, we describe a novel-humanized mouse model utilizing human induced pluripotent...

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PMID: 38032195
DOI: 10.1128/jvi.01595-23

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