Article

Microglia replacement effectively attenuates the disease progress of ALSP in the mouse model and human patient

2024-06-11

Abstract excerpt

Microglia play critical roles in the brain physiology and pathology. CSF1R is primarily expressed in microglia. The mono-allelic CSF1R mutation causes adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a lethal neurological disease and no rational cure in clinical trials. There are no animal models mimicking human ALSP. In this study, we first developed mouse models based on human AL...

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Literature Corpus work: c3802ace-8cfa-589d-985e-986f25cbb5e1
DOI: 10.1101/2024.06.11.598496

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