Article

Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer’s Disease Model

2023-11-14

Abstract excerpt

<h4>SUMMARY</h4> Despite strong evidence supporting the involvement of both apolipoprotein E4 (APOE4) and microglia in Alzheimer’s Disease (AD) pathogenesis, the effects of microglia on neuronal APOE4-driven AD pathogenesis remain elusive. Here, we examined such effects utilizing microglial depletion in a chimeric model with human neurons in mouse hippocampus. Specifically, we transplanted homozygous APOE4, isoge...

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Literature Corpus work: eb0dc40d-6e05-5f16-a91a-e88da8c67963
DOI: 10.1101/2023.11.10.566510

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