Article

Transplantation of wild-type hematopoietic stem and progenitor cells rescue Alzheimer’s disease in a mouse model and highlights the central role of microglia in disease pathogenesis

2022-05-02

Abstract excerpt

Alzheimer’s disease (AD) is the most prevalent cause of dementia, but still no effective treatment exists. Microglia have been implicated in AD pathogenesis, but their role is still matter of debate. Our study represents direct evidence that microglia play a key role in disease progression, and that replacing diseased APP/PSEN1 microglia via single systemic wild-type (WT) hematopoietic stem and progenitor cell (HS...

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Literature Corpus work: 96b9ee05-9069-5179-bbe6-a8bbd4e0def1
DOI: 10.21203/rs.3.rs-1602615/v1

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