Article

Functional Mature Human Microglia Developed in Human iPSC Microglial Chimeric Mouse Brain

2019-03-31

Abstract excerpt

Microglia, the brain-resident macrophages, exhibit highly dynamic functions in neurodevelopment and neurodegeneration. Human microglia possess unique features as compared to mouse microglia, but our understanding of human microglial functions is largely limited by an inability to obtain human microglia under homeostatic states. We developed a human pluripotent stem cell (hPSC)-based microglial chimeric mouse brain...

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Literature Corpus work: 37b354a5-d5c3-5e86-87b7-6dd34182111e
DOI: 10.1101/594721

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